Ryukyu is the hero Nejire was working with for her Hero Work-Studies and the two seem to have a fairly close relationship as teacher and student. Nejire admires Ryukyu a lot and is very attached to her, listening carefully when he speaks to her and following his orders without hesitation. Ryukyu hired Nejire to work in her agency and because of that, she is aware of Nejire's abilities and skills and recognizes her talent.
Ryukyu also seems to value Nejire's opinion, as she was willing to listen to Nejire's offer to recruit Ochaco and Tsuyu in her office. Unlike other people, Ryukyu is not bothered by Nejire's childish and noisy personality and treats her like a younger sister. Ryukyu congratulated her when she saw Nejire improve the range of her attacks and Nejire happily ran to hug her before Sir Nighteye's meeting, while Ryukyu did not object to Nejire hugging her and even opens her arms to receive the hug.
When Ryukyu transformed into his Dragon form to trap Rikiya Katsukame, Nejire was surprised but immediately led Ochaco and Tsuyu to help her and when Rikiya broke free from the Police Force, Ryukyu relied heavily on Nejire's abilities in the fight against Rikiya Katsukame and helped her up after Nejire got tired from the fight. During the Paranormal Liberation War, when she saw Ryukyu seriously injured in the fight against Tomura Shigaraki, Nejire displayed immense anger against the responsible Villain, a side she rarely expresses.
Thanks to Nejire's recommendation, Ochaco Uraraka and Tsuyu Asui were hired by Ryukyu for internship and both girls got excited for the opportunity.
Both Ochaco and Tsuyu respects the Pro Hero and are grateful that she accepts them as intern. On the other hand, Ryuko believes that they both have potential and welcomes her agency while saying that the internship will help them develop their fighting skills.
Ryuko trusted Ochaco and Tsuyu to go to Sir Nighteye's meeting and deemed them fit to go on the operation against the Shie Hassaikai and the rescue of Eri. During the Ryukyu mission, Ochaco, Tsuyu and Nejire defeated Rikiya Katsukame and demonstrated good teamwork. Ryukyu entrusted Ochaco and Tsuyu with Sir Nighteye's safety and re-recruits them during the return from internships.