The Central Hospital is a huge building located in the middle of the city, rising above the surrounding buildings.
The interior looks like a normal hospital, although it has more advanced equipment for treating patients.
Several years ago, when Toya Todoroki began to show burns on his body due his Quirk, Enji and Rei took their son to Central Hospital to discuss his condition. The doctor explains that while Toya had inherited the powerful fire Quirk from Enji, unfortunately he also inherited his mother's physical condition, meaning his body was meant to withstand freezing temperatures but not fire.
In order to win favor with the League of Villains by killing a Hero, Hawks convinced Best Jeanist to help fake his death. Inspired by the designs of the Nomu, Central Hospital put Best Jeanist into a "death-like state", allowing Hawks to trick the Villains. Shortly before the Paranormal Liberation War, Hawks secretly sent the body back to Central Hospital, who then revived Best Jeanist back to normal.
In the aftermath of the War, the heroes were unable to prevent Tomura Shigaraki and several of his allies from escaping, which resulted in several of them who participated being killed in the conflict, as well as many being fatally wounded. Most of these wounded heroes were taken to Central Hospital for their recovery treatment.
- Izuku Midoriya (Formerly)
- Katsuki Bakugo (Formerly)
- Shoto Todoroki (Formerly)
- Keigo Takami (Formerly)
- Enji Todoroki (Formerly)
- Sorahiko Torino
- Shota Aizawa
- Denki Kaminari (Formerly)
- Fumikage Tokoyami (Formerly)
- Toya Todoroki (Formerly)
- The design of several of the Central Hospital doctors are based on characters from the Super Mario franchise.